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KMID : 0861020060210030069
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Korea Journal of Herbology
2006 Volume.21 No. 3 p.69 ~ p.74
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Effect of A Combined Prescription on Liver Injury of Rats by $CCl_4$
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Cho Su-In
Kim Hyung-Woo
Kim Sung-Wook
Yoon Yeo-Choong
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Abstract
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Objectives : This study was undertaken to determine if a combined(SPe) has a protective effect against functional failure induced by $CCl_4$ in rat liver.
Methods : Acute liver injury which initiated from free radical induced by $CCl_4$, were applied to rats and data were obtained. Liver injury was estimated by measuring aspartate aminotransferase(AST) and alanine aminotransferase(ALT) activity in serum. Lipid peroxidation was examined by measuring malondialdehyde, a product of lipid peroxidation. GSH activities in liver tissues were also measured.
Results : When rats were treated intraperitoneally with $CCl_4$, serum AST and ALT were increased compared with the control, which was significantly inhibited by pretreatment of SPe. SPe also prevented reduction in GSH induced by $CCl_4$.
Conclusion : Above results suggest that SPe exerts protective effect against $CCl_4$ by its antioxidant action in liver tissues. Thus, SPe may be used in prevention and treatment of drug-induced liver cell injury. However, the precise mechanisms of SPe protection remain to be determined.
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KEYWORD
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CCl4, liver injury, oxidation, AST, ALT
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